There's nothing I can see from the log, so you'll have to wait on Mefisto for that.
In the meantime you can try to add the game to your
DEP List. Also make sure your virus scanner isn't causing any problems and you don't have the game running on a location you shouldn't (like a folder on your desktop).
Also try to see if your problem is related to directx, by forcing the '
windib' video driver(with the launcher, run options, force driver, type it in the input field there).
If all that fails, it might also help to share a log file from the latest nightly build from keeperfx.exe (non-heavylog version). You can do so here, but have better visibility if you raise an issue on the issue tracker
here.